CD8A Mouse Monoclonal Antibody [Clone ID: 4B11]

Specifications

Product Data
Clone Name	4B11
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Frozen Sections: 1/50. Immunohistochemistry on Paraffin Sections: 1/50. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections; 1mM EDTA pH8.0 is recommended for this purpose. Western Blot: 1/25.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide derived from CD8 alpha chain sequence.
Specificity	This antibody recognizes the Human CD8 cell surface antigen, a 32kD glycoprotein expressed by the cytotoxic/suppressor subset of T-cells and weakly by NK cells.
Formulation	State: Lyophilised Tissue Culture Supernatant Preservative: 0.09% Sodium Azide
Reconstitution Method	Restore with 1 ml distilled water.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD8a molecule
Database Link	Entrez Gene 925 Human UniProt ID P01732
Background	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data

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