CD70 Mouse Monoclonal Antibody [Clone ID: Bu69]

Specifications

Product Data
Clone Name	Bu69
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on frozen sections. Flow Cytometry: 1/50 - 1/200.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises CD70, a 29kD type II transmembrane protein that belongs to the tumour necrosis factor (TNF) family. CD70 is expressed on a small number of activated T-cells and the majority of activated B-cells. Interaction of CD70 with its receptor, CD27, is thought to play an important role in lymphocyte activation, proliferation, survival and differentiation.
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD70 molecule
Database Link	Entrez Gene 970 Human UniProt ID P32970
Background	CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Synonyms	CD27 ligand, CD27L, CD27LG, TNFSF7
Reference Data
Protein Families	ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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