ITGAM Mouse Monoclonal Antibody [Clone ID: CC126]

Specifications

Product Data
Clone Name	CC126
Applications	FC
Recommend Dilution	Flow Cytometry: 1/10; use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
Reactivity	Bovine, Goat, Sheep
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises the CD11b cell surface antigen.
Formulation	PBS Label: FITC State: Liquid purified IgG Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide Label: Fluorescein Isothiocyanate Isomer 1 Absorption emission: 490 nm / 525 nm
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Database Link	UniProt ID A2TJJ2
Background	CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.
Synonyms	ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1
Reference Data

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