EDG6 (S1PR4) Mouse Monoclonal Antibody [Clone ID: 1]

Specifications

Product Data
Clone Name	1
Applications	FC, WB
Recommend Dilution	Western Blot. Flow Cytometry: Use 1 µg/10e6 cells. NOTE: Epitope for the antibody is the C-terminal of the EDG6 protein. The C-terminal is an intracellular region and cells need to be permeablized prior to staining with antibody.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from mice immunized with Unique synthetic peptide derived from the C-terminal of the EDG6 (S1P4) protein and mouse myeloma cells.
Specificity	Recognizes EDG-6/S1P4 (C-term).
Formulation	PBS containing containing 1% BSA as stabilizer and 0.1% antimycotic as a preservative Label: FITC State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein A/G Chromatography
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	sphingosine-1-phosphate receptor 4
Database Link	Entrez Gene 8698 Human UniProt ID O95977
Background	EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4).
Synonyms	EDG-6
Reference Data

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