LEF1 (all isoforms) Mouse Monoclonal Antibody [Clone ID: 1C3.1D10]

Specifications

Product Data
Clone Name	1C3.1D10
Applications	WB
Recommend Dilution	Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full length LEF-1 protein.
Specificity	This antibody detects all LEF-1 isoforms by Western blot and does not cross-react with TCF-1 or TCF-4. Recognizes an epitope in amino acids 256-308 of LEF-1. This region is between the transactivation domain and the HMG binding domain of LEF-1 and is conserved in all LEF-1 isoforms.
Formulation	PBS containing 0.08% Sodium Azide as preservative State: Purified State: Liquid (sterile filtered) purified IgG fraction.
Concentration	lot specific
Purification	Protein A/G Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	lymphoid enhancer binding factor 1
Database Link	Entrez Gene 51176 Human UniProt ID Q9UJU2
Background	Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others.
Synonyms	Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha
Reference Data

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