alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 4D6]

Specifications

Product Data
Clone Name	4D6
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western/Dot Blot: 1/100-1/10,000. Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Embedded Tissues: 1/100-1/1000 (No formic Acid, Enzyme or HIER required).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified E. coli produced Human Alpha-Synuclein.
Specificity	This antibody recognizes Human Alpha-Synuclein. Other species not tested.
Formulation	PBS State: Purified State: Liquid purified Ig fraction from Tissue Culture Supernatant Preservative: None
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	synuclein alpha
Database Link	Entrez Gene 6622 Human UniProt ID P37840
Background	Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.
Synonyms	NACP, PARK1
Reference Data

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