DAXX Mouse Monoclonal Antibody [Clone ID: DAXX-03]

Specifications

Product Data
Clone Name	DAXX-03
Applications	IF, IP, WB
Recommend Dilution	Immunoprecipitation. Western Blotting: 2 μg/ml. Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	His6-tagged protein corresponding to amino acids 580-740 of human Daxx.
Specificity	The antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein.
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein A affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	death-domain associated protein
Database Link	Entrez Gene 1616 Human UniProt ID Q9UER7
Background	Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
Synonyms	BING2, DAP6, EAP1
Reference Data

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