DcR2 (TNFRSF10D) Mouse Monoclonal Antibody [Clone ID: TRAIL-R4-01]

Specifications

Product Data
Clone Name	TRAIL-R4-01
Applications	FC
Recommend Dilution	Suitable for use in Flow Cytometry (1-5 µg/ml).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Specificity	This antibody reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Formulation	PBS, pH 7.4 without preservatives State: Azide Free State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Protein A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles.
Gene Name	tumor necrosis factor receptor superfamily member 10d
Database Link	Entrez Gene 8793 Human UniProt ID Q9UBN6
Background	TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Synonyms	TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4
Reference Data

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