Mistletoe Lectin Mouse Monoclonal Antibody [Clone ID: 2G8-F7]

Specifications

Product Data
Clone Name	2G8-F7
Applications	ELISA
Recommend Dilution	ELISA.
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Mistletoe Lectin
Specificity	Recognizes recombinant Mistletoe Lectin.
Formulation	PBS, pH 7.4 State: Purified State: Lyophilized ThioSorb M purifed Ig fraction from Cell Culture Supernatant
Reconstitution Method	Restore in aqua bidest to 1 mg/ml
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Background	Mistletoe lectin I (ML-I) is a type II ribosome-inactivating protein, which inhibits the protein biosynthesis at the ribosomal level. ML-I is composed of a catalytically active A-chain with rRNA N-glycosidase activity and a B-chain with carbohydrate binding specificities. Using comparative solid-phase binding assays along with electrospray ionization tandem mass spectrometry, ML-I was shown to preferentially bind to terminally α2−6-sialylated neolacto series gangliosides from human granulocytes. Researchers across Europe (centres include Moscow, Berlin and London) have been investigating what specific properties of Viscum album could affect cancer cells. They have confirmed that some chemicals in European mistletoe can have anticancer properties. These properties are linked to various cytotoxic and immuno-modulatory compounds found in mistletoe, mainly the chemicals known as Viscotoxins and Mistletoe Lectins.
Reference Data

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