Sponge Hsp70 Mouse Monoclonal Antibody [Clone ID: IVF5]

Specifications

Product Data
Clone Name	IVF5
Applications	ELISA, IHC, IP, WB
Recommend Dilution	ELISA: 1/5,000. Western blot: 1/500. Immunoprecipitation: 1/50. Immunohistochemistry: 1/50.
Reactivity	Geodia cydonium
Host	Mouse
Clonality	Monoclonal
Immunogen	HSP70 from Geodia cydonium.
Specificity	This antibody detects HSP70.
Formulation	50mM TRIS pH 7.4 State: Cell culture supernatant, Purified State: Lyophilized IgG fraction
Reconstitution Method	Restore in aqua bidest to 1 mg/ml.
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Database Link	UniProt ID Q24952
Background	Heat shock proteins (HSPs) or stress response proteins (SRPs) are synthesized in variety of environmental and pathophysiological stressful conditions. Many HSPs are involved in processes such as protein denaturation-renaturation, folding-unfolding, transport-translocation, activation-inactivation, and secretion. HSP70 is found to be associated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and other unknown proteins. Also, HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs, and other damaging conditions. Heat shock proteins are produced by prokaryotic and eukaryotic cells, and are among the most conserved molecules in phylogeny. Eukaryotic cells contain an HSP70 multigene that differ in their intracellular location and regulation. Members of the HSP70 family play a major role in the folding, unfolding and translocation of polypeptides as well as in the assembly and disassembly of oligomeric protein complexes, as well as in the immune response. HSP72 was found to increase dramatically in the brains of Alzheimer’s disease patients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. HSP70 concentrates in nuclei during heat shock and returns to the cytoplasm when the shock is removed.
Synonyms	Heat Shock Protein 70
Reference Data

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