Properdin (CFP) Mouse Monoclonal Antibody [Clone ID: 10-18]

Specifications

Product Data
Clone Name	10-18
Applications	ELISA, FN, IHC
Recommend Dilution	ELISA. Functional Assays. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Native purified factor P from human serum.
Specificity	This antibody recognises human factor P, a 53 kDa glycosylated protein present in blood serum.
Formulation	Borate buffered saline pH 8.2 containing 0.02% Sodium Azide State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor properdin
Database Link	Entrez Gene 5199 Human UniProt ID P27918
Background	Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.
Synonyms	CFP, PFC, Complement factor P
Note	This antibody is reported to inhibit the function of factor P. Removal of Sodium Azide is recommended prior to use in functional assays.
Reference Data
Protein Families	Secreted Protein

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