TAC1 Rat Monoclonal Antibody [Clone ID: NC1/34]

Specifications

Product Data
Clone Name	NC1/34
Applications	IF, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: 1/100-1/200. Immunohistochemistry on Paraffin Sections: 1/100-1/200 (Pre-treatment is not required). Immunofluorescence: This antibody has been used for the localisation of Substance P in tissue sections by immunofluorescence and PAP staining in nervous systems of experimental animals and man. Please refer to the Cuello references listed below. It has also been successfully applied in archive post-mortem tissues of the Human brain, see Mai and Pioro references.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	Substance P conjugated to Bovine Serum Albumin.
Specificity	This antibody recognizes the COOH terminal end of Substance P, a short polypeptide neurotransmitter that regulates the excitability of dorsal horn nociceptive neurons. 5% reactivity is observed with Eledoisin. It does not react with Leu or Met-Enkephalin, Somatostatin or beta-Endorphin.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant containing 0.09% Thiomersal
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tachykinin precursor 1
Database Link	Entrez Gene 6863 Human UniProt ID P20366
Background	Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.
Synonyms	Substance-P
Reference Data
Protein Families	Druggable Genome, Secreted Protein

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.