Thyroglobulin (TG) Mouse Monoclonal Antibody [Clone ID: BGN/6E10]

Specifications

Product Data
Clone Name	BGN/6E10
Applications	ELISA
Recommend Dilution	ELISA: This antibody is suitable for use as a Capture antibody in a Sandwich ELISA with BGN/6D7 (BM733) as the Detection antibody.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Native Human Thyreoglobulin.
Specificity	Reacts with different epitope to clone BGN/6D7 (BM733) and can be used as the coated antibody in 2 site assay with this clone.
Formulation	PBS, pH 7.2 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thyroglobulin
Database Link	Entrez Gene 7038 Human UniProt ID P01266
Background	Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
Synonyms	Thyreoglobulin, TGN
Reference Data

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