Adenovirus (Hexon) Mouse Monoclonal Antibody [Clone ID: 8C4]

Specifications

Product Data
Clone Name	8C4
Applications	ELISA, FC, ID
Recommend Dilution	ELISA. Immunodiffusion. Immunohistochemistry on frozen sections.
Reactivity	Adeno-Associated Virus 1, Canine Adenovirus 1, Bovine Adenovirus 1
Host	Mouse
Clonality	Monoclonal
Immunogen	Hexon antigen of human and canine adenoviruses (Type 1).
Specificity	Reacts to human, canine, bovine, monkey and rat adenovirus. It is likely that the antibody will react with all mammalian adenoviruses
Formulation	PBS containing 0.09% Sodium Azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Background	Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease. Hexon protein is a major coat protein of adenoviruses. Adenoviruses capsids have three principal protein components: the hexon, the penton, and the fiber. Hexon consists of three subunits together forming two major components of different morphological symmetry. A triangular top with three towers of density is superimposed on a more bulky pseudo hexagonal base. The symmetry of the top is in accord with the trimeric nature of hexon, but that of the base derives from the molecular function, which is to provide a densely packed impenetrable protective outer layer for the virion.
Reference Data

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