Cortisol Mouse Monoclonal Antibody [Clone ID: CORT-2]

Specifications

Product Data
Clone Name	CORT-2
Applications	ELISA
Recommend Dilution	Can be used in competitive assay of Cortisol.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Cortisol-3 (CMO) -BSA. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Specificity	This antibody recognizes Cortisol-BSA conjugate and free Cortisol. There is no cross-reactivity with BSA. Cross-reactivity: (50% displacement of cortisol-3-125-Iodine) Cortisol: 100% Corticosterone: 49% 17-Hydroxyprogesterone: 0%
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction (>95% pure).
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Background	Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
Synonyms	Hydrocortisone
Reference Data

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