GSK3 beta (GSK3B) pSer9 (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 2D3]

Specifications

Product Data
Clone Name	2D3
Applications	ELISA, WB
Recommend Dilution	Western Blot: 0.5 µg/ml for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubation buffer. Positive Control: Cell lysate from pervanadate treated HepG2 cells. ELISA: 0.05 µg/ml.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic phosphopeptide conjugated to KLH.
Specificity	This antibody specifically recognizes GSK3beta phosphorylated at Ser 9 at 46 kDa. The antibody does not crossreact with GSK3alpha pSer21.
Formulation	PBS/0.09% Na-Azide/PEG and Sucrose/50% Glycerol State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Size
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	glycogen synthase kinase 3 beta
Database Link	Entrez Gene 2932 Human UniProt ID P49841
Background	Glycogen Synthase Kinase 3 beta (GSK3beta) is a serine/threonine kinase that is acting independently of most signal transduction pathways. The activity of GSK3beta can be modulated by phosphorylation of Ser9 and Tyr215 in the activation loop. GSK3beta plays a crucial role in phosphorylation of beta-catenin and thus is an important kinase involved in the regulation of beta-catenin/wnt-signaling.
Synonyms	GSK-3 beta, Glycogen synthase kinase-3 beta, GSK3B
Reference Data

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