Calcipressin-1 (Isoform B) (1-117) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
Predicted MW	13 kDa
Concentration	lot specific
Purity	>90% >/= 90% by SDS PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 1 mM DTT, 10% Glycerol
Preparation	Liquid purified protein
Protein Description	Recombinant human DSCR1 was expressed in E.coli and purified by using conventional chromatography techniques.
Note	NCBI Accession: NP_981962
Storage	Store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001272318
Locus ID	1827
UniProt ID	P53805
Cytogenetics	21q22.12
Synonyms	ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
Summary	The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Protein Families	Transcription Factors

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