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Serotonin N acetyltransferase (AANAT) (NM_001166579) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC229773L3V
- LentiORF®
-
Lenti ORF particles, AANAT (Myc-DDK-tagged)-Human aralkylamine N-acetyltransferase (AANAT), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 7,410.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
CNY 2,950.00
Specifications
| Product Data | |
| Product Name | Serotonin N acetyltransferase (AANAT) (NM_001166579) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | DSPS; SNAT |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001166579 |
| ORF Size | 756 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC229773).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001166579.1, NP_001160051.1 |
| RefSeq Size | 1935 bp |
| RefSeq ORF | 759 bp |
| Locus ID | 15 |
| Protein Pathways | Metabolic pathways, Tryptophan metabolism |
| MW | 28.4 kDa |
| Gene Summary | The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes
,null,
Hepatology (Baltimore, Md.)
,PubMed ID 23080076
[AANAT]
|
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Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma; its synthesis is reduced favoring cholangiocarcinoma growth
,null,
American Journal of Physiology - Gastrointestinal and Liver Physiology
,PubMed ID 21778461
[AANAT]
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