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LYAR (NM_001145725) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC226844L3V
- LentiORF®
-
Lenti ORF particles, LYAR (Myc-DDK tagged) - Human Ly1 antibody reactive homolog (mouse) (LYAR), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | LYAR (NM_001145725) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ZC2HC2; ZLYAR |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001145725 |
| ORF Size | 1137 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC226844).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001145725.1, NP_001139197.1 |
| RefSeq Size | 1486 bp |
| RefSeq ORF | 1140 bp |
| Locus ID | 55646 |
| MW | 43.6 kDa |
| Gene Summary | Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).[UniProtKB/Swiss-Prot Function] |
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