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E2F4 (NM_001950) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC207699L4V
- LentiORF®
-
Lenti ORF particles, E2F4 (mGFP-tagged) - Human E2F transcription factor 4, p107/p130-binding (E2F4), 200ul, >10^7 TU/mL
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CNY 9,975.00
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CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | E2F4 (NM_001950) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | E2F-4 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001950 |
| ORF Size | 1239 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC207699).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001950.3 |
| RefSeq Size | 2100 bp |
| RefSeq ORF | 1242 bp |
| Locus ID | 1874 |
| Domains | E2F_TDP |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Cell cycle, TGF-beta signaling pathway |
| MW | 44 kDa |
| Gene Summary | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008] |
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