Superoxide Dismutase 1 (SOD1) (NM_000454) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC200725L1V
- LentiORF®
Lenti ORF particles, SOD1 (Myc-DDK tagged) - Human superoxide dismutase 1, soluble (SOD1), 200ul, >10^7 TU/mL
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CNY 7,410.00
Cited in 2 publications. |
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | Superoxide Dismutase 1 (SOD1) (NM_000454) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD; STAHP |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_000454 |
ORF Size | 462 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC200725).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000454.4 |
RefSeq Size | 981 bp |
RefSeq ORF | 465 bp |
Locus ID | 6647 |
Domains | sodcu |
Protein Families | Druggable Genome |
Protein Pathways | Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases |
MW | 15.9 kDa |
Gene Summary | The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020] |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
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Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3 β/β-catenin signaling
,null,
Toxicology and applied pharmacology
,PubMed ID 23707771
[SOD1]
|
Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells
,null,
Toxicology and applied pharmacology
,PubMed ID 21767558
[SOD1]
|
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