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NGAL (Lcn2) (NM_008491) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226233L3V
- LentiORF®
-
Lenti ORF particles, Lcn2 (Myc-DDK-tagged) - Mouse lipocalin 2 (Lcn2), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | NGAL (Lcn2) (NM_008491) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 24p3; AW212229; NRL; Sip24 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008491 |
| ORF Size | 600 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226233).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008491.1, NP_032517.1 |
| RefSeq Size | 853 bp |
| RefSeq ORF | 603 bp |
| Locus ID | 16819 |
| Gene Summary | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis (By similarity).[UniProtKB/Swiss-Prot Function] |
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