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Rara (NM_001176528) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225595L4V
- LentiORF®
-
Lenti ORF particles, Rara (GFP-tagged) - Mouse retinoic acid receptor, alpha (Rara), transcript variant 4, 200ul, >10^7 TU/mL
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CNY 10,070.00
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Specifications
| Product Data | |
| Product Name | Rara (NM_001176528) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Nr1b1; RAR; RARalpha1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001176528 |
| ORF Size | 1377 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225595).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001176528.1, NP_001169999.1 |
| RefSeq Size | 3179 bp |
| RefSeq ORF | 1380 bp |
| Locus ID | 19401 |
| Gene Summary | Receptor for retinoic acid (PubMed:17205979). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:17205979). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:17205979). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:17205979, PubMed:9230306, PubMed:19078967). Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (By similarity). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (PubMed:15901285). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (PubMed:15901285, PubMed:17905941). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (PubMed:10660575, PubMed:17905941). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (By similarity).[UniProtKB/Swiss-Prot Function] |
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