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Jarid2 (NM_021878) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222802L4V
- LentiORF®
-
Lenti ORF particles, Jarid2 (GFP-tagged) - Mouse jumonji, AT rich interactive domain 2 (Jarid2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 19,855.00
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Specifications
| Product Data | |
| Product Name | Jarid2 (NM_021878) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Jmj; jumonji |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_021878 |
| ORF Size | 3702 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222802).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_021878.3, NP_068678.1 |
| RefSeq Size | 5716 bp |
| RefSeq ORF | 3705 bp |
| Locus ID | 16468 |
| Gene Summary | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.[UniProtKB/Swiss-Prot Function] |
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