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Eps8 (NM_007945) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210818L4V
- LentiORF®
-
Lenti ORF particles, Eps8 (GFP-tagged) - Mouse epidermal growth factor receptor pathway substrate 8 (Eps8), 200ul, >10^7 TU/mL
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CNY 14,725.00
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Specifications
| Product Data | |
| Product Name | Eps8 (NM_007945) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW261790 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_007945 |
| ORF Size | 2466 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210818).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_007945.2 |
| RefSeq Size | 4567 bp |
| RefSeq ORF | 2466 bp |
| Locus ID | 13860 |
| Gene Summary | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.[UniProtKB/Swiss-Prot Function] |
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