Uchl3 (NM_016723) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR202766L4V
- LentiORF®
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Lenti ORF particles, Uchl3 (GFP-tagged) - Mouse ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (Uchl3), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
Product Data | |
Product Name | Uchl3 (NM_016723) Mouse Tagged ORF Clone Lentiviral Particle |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_016723 |
ORF Size | 690 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR202766).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_016723.2, NP_057932.2 |
RefSeq Size | 947 bp |
RefSeq ORF | 693 bp |
Locus ID | 50933 |
Gene Summary | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.[UniProtKB/Swiss-Prot Function] |
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