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Egln1 (NM_053207) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR200656L3V
- LentiORF®
-
Lenti ORF particles, Egln1 (Myc-DDK-tagged) - Mouse EGL nine homolog 1 (C. elegans) (Egln1), 200ul, >10^7 TU/mL
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CNY 7,410.00
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规格
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Specifications
| Product Data | |
| Product Name | Egln1 (NM_053207) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI503754; C1orf12; Hif-p4h-2; HIF-PH2; HPH-2; ORF13; Phd2; SM-20 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_053207 |
| ORF Size | 378 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR200656).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_053207.1, NP_444437.1 |
| RefSeq Size | 3524 bp |
| RefSeq ORF | 1203 bp |
| Locus ID | 112405 |
| Gene Summary | Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.[UniProtKB/Swiss-Prot Function] |
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