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Ackr3 (NM_007722) Mouse Tagged Lenti ORF Clone
CAT＃: MR205565L3
- LentiORF®
Lenti ORF clone of Cxcr7 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) receptor 7 (Cxcr7)
"NM_007722" in other vectors (4)
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CNY 4,750.00
Product images
CNY 600.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | AW541270; Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| E. coli Selection | Chloramphenicol (34 ug/mL) |
| Mammalian Cell Selection | Puromycin |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR205565).
|
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_007722 |
| ORF Size | 1089 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_007722.2, NP_031748.2 |
| RefSeq Size | 2052 bp |
| RefSeq ORF | 1089 bp |
| Locus ID | 12778 |
| UniProt ID | P56485 |
| Gene Summary | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC203863 | Ackr3 (untagged) - Mouse chemokine (C-X-C motif) receptor 7 (Cxcr7), (10ug) |
CNY 2,000.00 |
|
| MG205565 | Cxcr7 (tGFP-tagged) - Mouse chemokine (C-X-C motif) receptor 7 (Cxcr7) |
CNY 3,140.00 |
|
| MR205565 | Cxcr7 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) receptor 7 (Cxcr7) |
CNY 2,850.00 |
|
| MR205565L4 | Lenti ORF clone of Cxcr7 (mGFP-tagged) - Mouse chemokine (C-X-C motif) receptor 7 (Cxcr7) |
CNY 4,750.00 |
