TRAF5 Mouse Monoclonal Antibody [Clone ID: 55A219]

Specifications

Product Data
Clone Name	55A219
Applications	WB
Recommend Dilution	Western Blot: 2 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-TRAF5 monoclonal antibody was raised against a fusion protein corresponding to amino acids 77 to 186 of human TRAF5.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TNF receptor associated factor 5
Database Link	NP_665702 Entrez Gene 7188 Human UniProt ID O00463
Background	Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor . Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation.
Synonyms	MGC:39780; RNF84
Note	This antibody can be used in Western Blot where a 66 kDa band is seen (predicted molecular weight 66.8 kDa).
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Pathways in cancer, Small cell lung cancer

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