TEM7 (PLXDC1) Mouse Monoclonal Antibody [Clone ID: 197C193 (IM193)]

Specifications

Product Data
Clone Name	197C193 (IM193)
Applications	ICC/IF, IHC, IP, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry-Frozen), Immunohistochemistry-Paraffin: 2-5 ug/ml, Immunoprecipitation: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Western Blot
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Amino acids 409-425 (LQNNLSPKTKGTPVHLG) of human TEM7 were used to develop this monoclonal antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	plexin domain containing 1
Database Link	NP_065138 Entrez Gene 72324 MouseEntrez Gene 303505 RatEntrez Gene 57125 Human UniProt ID Q8IUK5
Background	Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
Synonyms	TEM3; TEM7
Note	Immunocytochemistry/Immunofluorescence: see Meng et al, 2007. Immunohistochemistry (frozen): see Lee et al, 2006. Immunohistochemistry (paraffin): 2-5 ug/ml; see Nanda et al, 2004 and Lee et al, 2005. Immunoprecipitation: see Nanda et al, 2004.
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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