alpha 1 Spectrin (SPTA1) Mouse Monoclonal Antibody [Clone ID: RBC2/3D5]

Specifications

Product Data
Clone Name	RBC2/3D5
Applications	IHC
Recommend Dilution	IHC: 1:10 - 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	spectrin alpha, erythrocytic 1
Database Link	NP_003117 Entrez Gene 6708 Human UniProt ID P02549
Synonyms	EL2; HPP; HS3; SPH3; SPTA
Note	Spectrin is an actin-crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. The gene is one member of a family of alpha- spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in the gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.Anti-spectrin is useful in the diagnosis of erythroid leukemias.
Reference Data

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