CoREST (RCOR1) Mouse Monoclonal Antibody [Clone ID: S72-8]

Specifications

Product Data
Clone Name	S72-8
Applications	IHC
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, ICC: 0.1-1ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 109-293 of human Co-Rest
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	REST corepressor 1
Database Link	NP_055971 Entrez Gene 217864 MouseEntrez Gene 102554884 RatEntrez Gene 23186 Human UniProt ID Q9UKL0
Background	The RCOR1 gene encodes a functional corepressor required for regulation of neural-specific gene expression . Co-Rest (corepressor for element-1-silencing transcription factor) is the primary cofactor of Rest, and recruits additional epigenetic factors similarily associated with gene activation and repression . Co-rest has been found to be an essential component of the repression mechanism used to block expression of type II sodium channel reporter genes in non-neuronal cell types . It has also been demonstrated that the corepressor function of Co-REST depends on an HDAC1/2-interacting region containing a SANT domain .
Synonyms	COREST; RCOR
Note	Detects ~66-80kDa (Depending on gel system used)
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Huntington's disease

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