ZGPAT Chicken Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Chicken
Clonality	Polyclonal
Immunogen	ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT.
Formulation	ZGPAT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ZGPAT Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	zinc finger CCCH-type and G-patch domain containing
Database Link	NP_115916 Entrez Gene 84619 Human UniProt ID Q8N5A5
Background	ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.
Synonyms	CCCH-type with G patch domain; GPATC6; GPATCH6; KIAA1847; MGC44880; OTTHUMP00000031593; OTTHUMP00000031594; OTTHUMP00000031596; RP4-583P15.3; ZC3H9; ZC3HDC9; zinc finger
Reference Data

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