PON1 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500. Flow Cytometry: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 121-149 amino acids from the Central region of human PON1.
Specificity	This antibody recognizes Human PON1 (Center).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	paraoxonase 1
Database Link	Entrez Gene 5444 Human UniProt ID P27169
Background	The enzyme encoded by this gene is an Arylesterase that mainly hydrolyzes Paroxon to produce p-Nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
Synonyms	PON-1, PON, Serum paraoxonase/arylesterase 1, PON 1, EC=3.1.1.2, EC=3.1.8.1, Serum aryldialkylphosphatase 1, A-esterase 1, Aromatic esterase 1, K-45
Note	Molecular Weight: 39731 Da
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Metabolic pathways

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