KCNMB1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of MaxiKbeta protein. (region surrounding Lys119)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 30 kDa
Gene Name	potassium calcium-activated channel subfamily M regulatory beta subunit 1
Database Link	Entrez Gene 16533 MouseEntrez Gene 29747 RatEntrez Gene 3779 Human UniProt ID Q16558
Background	The KCNMB1 gene, located on chromosome 5q34, contains four exons and encodes the 191 amino-acid protein MaxiKbeta subunit 1 (also designated calcium-activated potassium channel beta subunit, BK channel beta subunit, Slo-beta and KVCAbeta). MaxiKbeta subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKbeta subunit 1, one of four subunits in the MaxiKbeta family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKbeta subunit 1 associates with MaxiKalpha to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKbeta subunit 1 increases the sensitivity of the MaxiKalpha to calcium and voltage. The MaxiKalpha/beta1 channel is the most sensitive of all Maxi channels to calcium. MaxiKbeta plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.
Synonyms	subfamily M beta-1, Maxi K channel beta-1, BK channel beta-1, K VCAbeta-1, Slo-beta-1, Charybdotoxin receptor subunit beta-1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Other, Transmembrane
Protein Pathways	Vascular smooth muscle contraction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.