United States
Germany
Japan
United Kingdom
China
Ern1 (NM_023913) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226999L4V
- LentiORF®
-
Lenti ORF particles, Ern1 (GFP-tagged) - Mouse endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
Need custom lentivirus service?
Get a free quote
CNY 16,530.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | Ern1 (NM_023913) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9030414B18Rik; AI225830; C85377; Ire1a; Ire1alpha; Ire1p |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_023913 |
| ORF Size | 2931 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226999).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_023913.2, NP_076402.1 |
| RefSeq Size | 3976 bp |
| RefSeq ORF | 2934 bp |
| Locus ID | 78943 |
| Gene Summary | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11850408, PubMed:25164867). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:25164867). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11850408, PubMed:25164867). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11850408, PubMed:25164867). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
