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Ctcfl (NM_001081387) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222222L4V
- LentiORF®
-
Lenti ORF particles, Ctcfl (GFP-tagged) - Mouse CCCTC-binding factor (zinc finger protein)-like (Ctcfl), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 12,255.00
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规格
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Specifications
| Product Data | |
| Product Name | Ctcfl (NM_001081387) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Boris; OTTMUSG00000016680 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001081387 |
| ORF Size | 1908 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222222).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001081387.2, NP_001074856.1 |
| RefSeq Size | 3217 bp |
| RefSeq ORF | 1911 bp |
| Locus ID | 664799 |
| Gene Summary | Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.[UniProtKB/Swiss-Prot Function] |
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