Cav1 (NM_007616) Mouse Tagged ORF Clone
CAT#: MG201562
- TrueORF®
tGFP-tagged ORF clone of Mus musculus caveolin, caveolae protein 1 (Cav1)
ORF Plasmid: DDK
"NM_007616" in other vectors (4)
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CNY 2,850.00
Cited in 1 publication. |
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | Cav; Cav-1 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_007616 |
ORF Size | 534 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_007616.4 |
RefSeq Size | 2487 bp |
RefSeq ORF | 537 bp |
Locus ID | 12389 |
UniProt ID | P49817 |
Gene Summary | May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis
,Lin, X;Barravecchia, M;Matthew Kottmann, R;Sime, P;Dean, DA;,
Sci Rep
,PubMed ID 31873099
[CAV1]
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Documents
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC202054 | Cav1 (untagged) - Mouse caveolin 1, caveolae protein (Cav1), (10ug) |
CNY 2,000.00 |
|
MR201562 | Cav1 (Myc-DDK-tagged) - Mouse caveolin 1, caveolae protein (Cav1) |
CNY 2,400.00 |
|
MR201562L3 | Lenti ORF clone of Cav1 (Myc-DDK-tagged) - Mouse caveolin 1, caveolae protein (Cav1) |
CNY 4,750.00 |
|
MR201562L4 | Lenti ORF clone of Cav1 (mGFP-tagged) - Mouse caveolin 1, caveolae protein (Cav1) |
CNY 4,750.00 |