Sort1 (NM_001271599) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	2900053A11Rik; AI852375; Ntr3; Ntsr3
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC229056 representing NM_001271599 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCGGCCCCGGGGAGCTGCGGACGGCCTTTTGCGCTGGCCCCTCGGCCTCCTCCTGCTCCTTCAAC TGCTGCCTCCTGCCGCCGTCGGCCAGGACCGGCTGGACGCGCCGCCGCCGCCCGCGCCTCCTCTGCTGCG CTGGGCCGGTCCGGTCGGGGTGAGCTGGGGGCTGCGCGCCGCCGCGCCCGGGGGCCCCGTCCCCCGCGCT GGCCGTTGGCGCCGCGGCGCGCCCGCCGAGGACCAAGACTGCGGCCGCCTCCCGGACTTCATCGCCAAGC TGACCAACAATACGCACCAGCATGTCTTTGATGACCTCAGTGGCTCAGTGTCCTTGTCCTGGGTTGGAGA CAGCACTGGGGTTATTCTCGTCCTGACCACTTTCCAAGTGCCTCTGGTAATTGTGAGCTTTGGACAGTCC AAGTTGTATCGAAGTGAGGATTATGGAAAGAACTTTAAGGATATTACAAATCTCATCAATAACACCTTCA TTCGGACGGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGATACTAACAGCGGAGGTGTC CGGGGGAAGCCGAGGCGGAAGAGTGTTCAGGTCATCAGACTTTGCCAAGAACTTTGTGCAAACAGATCTC CCCTTTCATCCTCTGACGCAGATGATGTACAGCCCTCAGAATTCTGATTACCTGTTAGCTCTCAGCACCG AAAATGGCCTGTGGGTGTCCAAGAATTTTGGGGAAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGC CAAATGGGGACCAAACAACATCATCTTCTTTACCACCCATGTGAATGGCTCCTGCAAAGCTGATCTTGGT GCCCTGGAATTATGGAGAACATCCGACTTGGGAAAAACCTTCAAAACCATTGGTGTGAAAATCTACTCCT TTGGTCTTGGGGGCCGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGACACAACAAGAAGGATCCATGT GTCAACAGACCAGGGGGACACATGGAGCATGGCACAACTTCCTTCTGTGGGACAGGAACAGTTCTACTCC ATCCTGGCAGCCAATGAGGACATGGTCTTCATGCATGTAGATGAACCTGGAGATACCGGGTTTGGCACCA TCTTTACCTCTGATGATCGAGGCATTGTCTACTCCAAGTCTCTGGACAGACATCTCTATACCACCACAGG CGGGGAGACGGACTTTACCAACGTGACTTCCCTCCGTGGGGTCTATATAACAAGCACGCTCTCAGAAGAT AACTCTATTCAGAGCATGATCACTTTTGACCAGGGAGGACGGTGGGAGCACCTGCGGAAGCCGGAGAACA GCAAGTGCGACGCTACCGCAAAGAACAAGAACGAGTGCAGCCTTCATATCCATGCTTCTTATAGCATCTC CCAGAAGCTAAACGTTCCAATGGCCCCACTTTCCGAGCCCAATGCTGTGGGCATAGTCATCGCTCACGGT AGTGTGGGAGATGCCATCTCGGTGATGGTCCCAGATGTGTACATCTCAGATGATGGGGGTTACTCCTGGG CGAAGATGCTAGAAGGACCACATTACTATACCATCCTGGACTCTGGAGGCATCATTGTGGCCATTGAGCA CAGCAACCGTCCTATCAATGTGATTAAGTTCTCCACAGATGAAGGCCAGTGCTGGCAGAGCTATGTGTTC ACACAGGAGCCCATCTACTTCACTGGGCTTGCTTCCGAGCCTGGAGCCAGGTCCATGAACATCAGCATCT GGGGATTCACAGAGTCTTTCATTACCCGCCAGTGGGTCTCCTACACAGTCGATTTCAAAGACATCCTTGA GCGGAATTGTGAAGAGGATGACTATACCACGTGGCTGGCACACTCCACAGACCCTGGAGATTACAAAGAC GGCTGCATTTTGGGCTATAAAGAACAGTTCCTACGGCTACGGAAGTCATCCGTCTGTCAGAATGGTCGAG ACTATGTTGTGGCCAAGCAGCCATCCGTCTGTCCGTGTTCCCTGGAGGACTTCCTCTGTGACTTTGGCTA CTTCCGTCCGGAGAACGCCTCAGAGTGCGTGGAGCAGCCTGAACTGAAGGGGCATGAGTTAGAGTTCTGT CTGTACGGCAAGGAGGAGCACCTGACAACAAATGGGTACCGGAAAATCCCAGGAGACAAATGCCAAGGTG GGATGAATCCCGCCAGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTCTTGAACCCCACAAA GCAGGACTCCCGCCCACAGGGACACAGCTTGTCCCAGAATCCAGCTCCGCCTCCTCTTGGATACACTGAA AACACACACTTCCTATCTCCTACCCAGAAGCAGAATTCCAAGTCAAATTCTGTCCCTATTATCCTGGCCA TCGTGGGACTGATGCTTGTCACAGTCGTAGCAGGAGTCCTCATTGTGAAGAAATATGTCTGTGGCGGAAG GTTCCTGGTGCACCGGTACTCGGTGCTACAGCAGCACGCAGAGGCTGACGGCGTAGAGGCTTTGGATTCA ACCTCCCACGCTAAAAGCGGATATCACGACGACTCAGATGAGGACCTCCTGGAATAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001271599
Insert Size	2577 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001271599.1, NP_001258528.1
RefSeq Size	6950 bp
RefSeq ORF	2577 bp
Locus ID	20661
UniProt ID	Q6PHU5
Gene Summary	Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

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