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QRICH1 (NM_017730) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC213114L3V
- LentiORF®
-
Lenti ORF particles, QRICH1 (Myc-DDK tagged) - Human glutamine-rich 1 (QRICH1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | QRICH1 (NM_017730) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | AB-DIP; VERBRAS |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_017730 |
| ORF Size | 2328 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC213114).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_017730.2, NP_060200.2 |
| RefSeq Size | 3331 bp |
| RefSeq ORF | 2331 bp |
| Locus ID | 54870 |
| Protein Families | Druggable Genome |
| MW | 86.4 kDa |
| Gene Summary | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).[UniProtKB/Swiss-Prot Function] |
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