United States
Germany
Japan
United Kingdom
China
QRICH1 (NM_017730) Human Untagged Clone
CAT＃: SC111309
QRICH1 (untagged)-Human glutamine-rich 1 (QRICH1), transcript variant 1
CNY 3,656.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AB-DIP; VERBRAS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_017730, the custom clone sequence may differ by one or more nucleotides
ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGC AACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCA GACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCT GGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGA TCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCCAGGTGCAGGTACAGCAGTCTCCGCAACAGGTCTCGGC TCAGCTCTCCCCACAACTCACCGTTCACCAGCCTACTGAGCAACCCATCCAGGTCCAGGTGCAGATCCAA GGCCAGGCACCACAGTCAGCAGCCCCCTCCATTCAGACCCCGTCTCTGCAGAGTCCCAGTCCCTCGCAGC TGCAAGCAGCTCAGATCCAGGTGCAGCACGTGCAAGCAGCCCAGCAGATCCAGGCTGCAGAAATCCCGGA GGAGCACATCCCACATCAGCAAATCCAGGCTCAGCTGGTGGCTGGCCAGTCTCTTGCTGGTGGTCAGCAG ATCCAAATCCAGACCGTGGGTGCCCTTTCCCCACCACCATCCCAGCAGGGCTCACCCCGGGAAGGGGAGC GGCGGGTTGGCACGGCCAGTGTCCTCCAACCAGTGAAGAAGCGCAAAGTGGACATGCCCATCACTGTGTC CTACGCCATCTCAGGGCAGCCGGTGGCCACCGTGCTGGCCATTCCACAGGGCCAGCAGCAGAGTTATGTG TCTTTGAGGCCAGACTTACTGACAGTAGACAGTGCCCACCTGTACAGTGCCACTGGGACCATTACTAGCC CTACAGGAGAAACCTGGACCATCCCTGTTTATTCTGCCCAGCCCCGGGGGGACCCTCAGCAGCAGAGCAT TACCCACATTGCCATTCCCCAGGAAGCCTACAACGCAGTTCACGTCAGTGGCTCACCCACAGCCCTGGCA GCTGTTAAGCTGGAGGATGACAAGGAGAAGATGGTGGGCACCACATCTGTAGTGAAAAACTCCCATGAAG AGGTAGTGCAGACCCTTGCAAACTCTCTCTTTCCAGCACAGTTCATGAATGGCAACATCCACATTCCAGT GGCTGTGCAGGCTGTGGCAGGCACGTACCAGAATACGGCTCAAACTGTCCATATATGGGACCCCCAACAG CAGCCGCAGCAGCAAACTCCCCAGGAACAGACACCACCACCACAGCAGCAGCAGCAGCAACTCCAAGTTA CTTGTTCAGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACT TCTGCTTCCAAATTCTTTGAAGCCAGAAGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAAT GCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGCCAACTGCTGCGATTCCAGG AAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAA TGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTT GAAAATGGAAGGGTAGATGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAG TTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTATGTCTTGCCCAGCCACGTGACTGAGGAGAT GCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATGTTCTTTAAT ACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGA CAAAGAAGAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACA CCAGACTGGCCAGAAAGTTACAGATGACATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGA TGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTGAAAGGCCGGAATGACACCT TTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAG AGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCC AATGCAAGCACTATGCACTGA >OriGene 5' read for NM_017730 unedited
TTAGGATTTTGTAATACGACTTACTATAGGGNNCGGCCGCGCAATTCGGCACGAGGCGCA AAGTGGACATGCCCATCACTGTGTCCTACGCCATCTCAGGGCAGCCGGTGGCCACCGTGC TGGCCATTCCACAGGGCCAGCAGCAGAGTTATGTGTCTTTGAGGCCAGACTTACTGACAG TAGACAGTGCCCACCTGTACAGTGCCACTGGGACCATTACTAGCCCTACAGGAGAAACCT GGACCATCCCTGTTTATTCTGCCCAGCCCCGGGGGGACCCTCAGCAGCAGAGCATTACCC ACATTGCCATTCCCCAGGAAGCCTACAACGCAGTTCACGTCAGTGGCTCACCCACAGCCC TGGCAGCTGTTAAGCTGGAGGATGACAAGGAGAAGATGGTGGGCACCACATCTGTAGTGA AAAACTCCCATGAAGAGGTAGTGCAGACCCTTGCAAACTCTCTCTTTCCAGCACAGTTCA TGAATGGCAACATCCACATTCCAGTGGCTGTGCAGGCTGTGGCAGGCACGTACCAGAATA CGGCTCAAACTGTCCATATATGGGACCCCCAACAGCAGCCGCAGCAGCAAACTCCCCAGG AACAGACACCACCACCACAGCAGCAGCAGCAGCAACTCCAAGTTACTTGTTCAGCTCAAA CTGTCCAGGTTGCCTGAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGC TTTCAATTCTTTGAAGCCAGAAGAAGGGCTTGAAGTATGAAAAAACTGGGCCAGACCAAG ATGCTGTACTAGAGGAAGATGCTCAGAACAGATTGCACCCATTGGGAAGCGCCCACTGCT GCGATTCCAGAAGATCTCATCTCTTTGCTGTGGCAGAGTTGAATATGGCCTCTGTCTTAT GACACCGGAAGCTCGAATATGGAGAAGTGAACCT >OriGene 3' read for NM_017730 unedited
GCACGCAATCTATAGTCGAGNNNTTTTTTTTTTTTTTTTTTTTTTTTTGGTGAAAAAACG TGCTTGTCATTCTTAATAAACAACTAGAGTAAGAATACCTAAGAGAAACAGAGTGGTATC TTTATATGATACACAAGTGTATGTTACAAGAATTCCATCAGGCACAGGAGCCTCAGGTTT TAAGGCCTCAATGTTAGGCCAACAAAAAAAAAAAAGGCATGGGAAAGTTTTTACTTTTAC ATCTAAAATGTCACTTGTCATAAAGGAGGGTGTAATAGAAATTGGCTTTAATAAATCATA ATTGAAGTTCCCCTCATTTTTCTTCCATTAAGATGCTAAGTTTATGTCTGATCATGAAGA AAGAAAAGAACATCGTTCCCCTGTGGTCAGCAAAGTCTGTCAGCCCAGTGGAAGTCGGCT GGGGAGATTCCCTCCAGGGTCCATCCATCATTAATTCCATCTCTCTTGAAGATGGAAAGG GGCCACATTTCTTTTCACAGTCCAAGCCCTTTCCCCAGGCCCCAGACAAAAAAGAGTCAG CCAGCAACTTTCTAGGACATATGACACTCAAGGAAACCCAGAGCCACCATCGGCTGAAGA GTCTGCCGCAGCAAGTTTATGAAGATGCAAAGGGGGCAAAGNTTTCTTTTTATTTTAAAC AGAAGCAGCCTGAAAGGCTTCGCTACTACCCCAATAAAAAAAAGAAAAAAAAAATGGAGG CCTCTTCTTTAGTGTGAAAGTCTGTCTGGGTTTTCCTGGCTGGTTTCTCTTGTGCATGGN CAAGCATCTCATGCATTATGCTGCACTGGCCCTGCGATGCCCTCTGATTTCTCTATCACC AGACCGGTNAGCATTGGCCATCGCTCTTGCTGATAGCTGACTGATACANATTGGCTGTTG GGGGCACACTGGCTCAGGGTCAGTAAAGTGTCATTCCGCCCTTCACTCTGGGGCATTGAA AAGAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_017730 |
| Insert Size | 2500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_017730.1, NP_060200.1 |
| RefSeq Size | 3331 bp |
| RefSeq ORF | 1251 bp |
| Locus ID | 54870 |
| UniProt ID | Q2TAL8 |
| Protein Families | Druggable Genome |
| Gene Summary | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 encode the same protein. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213114 | QRICH1 (Myc-DDK-tagged)-Human glutamine-rich 1 (QRICH1), transcript variant 1 |
CNY 3,990.00 |
|
| RC213114L1 | Lenti ORF clone of Human glutamine-rich 1 (QRICH1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC213114L2 | Lenti ORF clone of Human glutamine-rich 1 (QRICH1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC213114L3 | Lenti ORF clone of Human glutamine-rich 1 (QRICH1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC213114L4 | Lenti ORF clone of Human glutamine-rich 1 (QRICH1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG213114 | QRICH1 (tGFP-tagged) - Human glutamine-rich 1 (QRICH1), transcript variant 1 |
CNY 4,370.00 |
|
| SC318260 | QRICH1 (untagged)-Human glutamine-rich 1 (QRICH1), transcript variant 1 |
CNY 7,220.00 |
