BTN2A2 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gln33-Val237
Tag	C-Fc
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Note	Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	10385
UniProt ID	Q8WVV5
Summary	Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naïve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

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