IL18 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) M1-D193
Tag	N-His
Buffer	Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Note	Recombinant Human IL-18 is produced by our E. coli expression system and the target gene encoding M1-D193 is expressed with a His tag at the N-terminus.
Storage	Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Locus ID	3606
UniProt ID	Q14116
Summary	Interleukin-18 (IL-18) is a secreted protein that belongs to the IL-1family. IL-18 is a proinflammatory cytokine and can be expressed by multiple types of cells, including endothelial and epithelial cells, keratinocytes, gamma delta T cells, and phagocytes. This cytokine can modulate both innate and adaptive. Once binding to IL18R1 and IL18RAP, it can form a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. The combination of IL-18 and IL-12 can induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.