Collagen type IV Bovine Protein

Specifications

Product Data
Description	Collagen type IV bovine protein, 0.5 mg
Species	Bovine
Protein Source	Placenta
Concentration	lot specific
Purity	>98% pure (chromatographically and immunologically pure).
Buffer	State: Liquid (sterile filtered) purified Ig fraction. Buffer System: 0.5 M Sodium Acetate, pH 4.5 containing 0, 01% Sodium Azide as preservative
Preparation	Liquid (sterile filtered) purified Ig fraction.
Applications	Suitable for use as a Control or Standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for Western blotting
Protein Description	This product has been prepared from Bovine Placenta and reacts with anti-Collagen Type IV. Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Storage	Store the antibody undiluted at 2-8°C.
Stability	Shelf life: 6 month from despatch.
Reference Data
RefSeq	NP_001290039
Locus ID	1282
Cytogenetics	13q34
Synonyms	BSVD; BSVD1; COL4A1s; PADMAL; RATOR
Summary	This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Protein Pathways	ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

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