Kallikrein-3 / PSA / KLK3 Human Protein

Specifications

Product Data
Description	Kallikrein-3 / PSA / KLK3 human protein, 0.1 mg
Species	Human
Protein Source	Seminal Fluid
Concentration	lot specific
Purity	>96% pure by SDS-PAGE
Buffer	State: Liquid (sterile filtered) purified protein. Buffer System: PBS, pH 7.5 containing 0.09% Sodium Azide as preservative.
Preparation	Liquid (sterile filtered) purified protein.
Applications	ELISA. Western Blot.
Protein Description	Prostate Specific Antigen (PSA) is a glycoprotein of approximately 30 kDa found mainly in prostatic tissue and seminal fluid. PSA is also present in small quantities in the serum of normal men and is often elevated in the presence of prostate cancer and in other prostate disorders.
Note	Caution: Tested and found negative for HBsAg and HIV-1 and 2, and HCV antibodies by FDA approved method, but according to laboratory practice should still be handled as though infectious.
Storage	Store undiluted at 2-8°C for one month or (in alqiuots) at -20°C for longer. Avoid repeated freezing and thawing
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001025218
Locus ID	354
Cytogenetics	19q13.33
Synonyms	APS; hK3; KLK2A1; PSA
Summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Pathways in cancer, Prostate cancer

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