RFXANK (NM_003721) Human Mass Spec Standard

Specifications

Product Data
Description	RFXANK MS Standard C13 and N15-labeled recombinant protein (NP_003712)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC220744
Predicted MW	28.1 kDa
Protein Sequence	Sequence Link (showhide) >RC220744 protein sequence Red=Cloning site Green=Tags(s) MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKHS TTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETV RFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL ARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_003712
RefSeq Size	1455
RefSeq ORF	780
Synonyms	ANKRA1; BLS; F14150_1; RFX-B
Locus ID	8625
Cytogenetics	19p13.11
Summary	Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Antigen processing and presentation, Primary immunodeficiency

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