Estrogen Related Receptor gamma (ESRRG) (NM_206595) Human Mass Spec Standard

CAT#: PH314462

ESRRG MS Standard C13 and N15-labeled recombinant protein (NP_996318)



  View other "Estrogen Related Receptor gamma" proteins (12)

Need it in bulk or customized?
Get a free quote

CNY 14,250.00


货期*
5周

规格
    • 10 ug

Product images

经常一起买 (2)
ESRRG (Estrogen Related Receptor gamma) mouse monoclonal antibody, clone OTI1E5 (formerly 1E5)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


Transient overexpression lysate of estrogen-related receptor gamma (ESRRG), transcript variant 1
    • 100 ug

CNY 4,840.00

Specifications

Product Data
Description ESRRG MS Standard C13 and N15-labeled recombinant protein (NP_996318)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC214462
Predicted MW 48.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_996318
RefSeq Size 5262
RefSeq ORF 1305
Synonyms ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3
Locus ID 2104
Cytogenetics 1q41
Summary This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

You may also need

其它Estrogen Related Receptor gamma产品

Customer Reviews 
Loading...