MTH1 (NUDT1) (NM_198948) Human Mass Spec Standard

CAT#: PH312655

NUDT1 MS Standard C13 and N15-labeled recombinant protein (NP_945186)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description NUDT1 MS Standard C13 and N15-labeled recombinant protein (NP_945186)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC212655
Predicted MW 18 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_945186
RefSeq Size 743
RefSeq ORF 468
Synonyms MTH1
Locus ID 4521
Cytogenetics 7p22.3
Summary Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]
Protein Families Stem cell - Pluripotency
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