Cytochrome C (CYCS) (NM_018947) Human Mass Spec Standard

Specifications

Product Data
Description	CYCS MS Standard C13 and N15-labeled recombinant protein (NP_061820)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC209724
Predicted MW	11.8 kDa
Protein Sequence	Sequence Link (showhide) >RC209724 protein sequence Red=Cloning site Green=Tags(s) MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKIGQAPGYSYTAANKNKGIIWGEDTLMEYLE NPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_061820
RefSeq Size	5544
RefSeq ORF	315
Synonyms	CYC; HCS; THC4
Locus ID	54205
Cytogenetics	7p15.3
Summary	This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Huntington's disease, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Small cell lung cancer, Viral myocarditis

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