ATP6V1B1 (NM_001692) Human Mass Spec Standard

CAT#: PH309462

ATP6V1B1 MS Standard C13 and N15-labeled recombinant protein (NP_001683)



  View other "ATP6V1B1" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ATP6V1B1)
    • 100 ug

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ATP6V1B1 mouse monoclonal antibody, clone OTI1H6 (formerly 1H6)
    • 100 ul

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Specifications

Product Data
Description ATP6V1B1 MS Standard C13 and N15-labeled recombinant protein (NP_001683)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC209462
Predicted MW 56.8 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001683
RefSeq Size 1956
RefSeq ORF 1539
Synonyms ATP6B1; DRTA2; RTA1B; VATB; VMA2; VPP3
Locus ID 525
Cytogenetics 2p13.3
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Epithelial cell signaling in Helicobacter pylori infection, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection
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